Nanoparticle encapsulation of HDACi with HA targeting in endometrial cancer models
Edwards, Kadie & Yao, Seydou & Pisano, Simone & Feltraccao, Veronica & Brusehafer, Katja & Samanta, Sumanta & Oommen, Oommen & Gazze, Salvatore & Paravati, Roberta & Maddison, Holly & Li, Chao & Gonzalez, Deyarina & Conlan, Robert & Francis, Lewis.
Bespoke nanoparticle systems can enhance drug delivery, preventing systemic exposure by modifying release kinetics and increasing tumour penetration. Flexible nano vector systems have led to selective tumour targeting through surface modifications and the addition of target moieties over expressed in the cancer microenvironment. As such nanomedicines are enabling drug re-purposing and renewed applications in solid tumour cancers. Here we present the nanoscale encapsulation of Vorinostat within a F127 Pluronic polymer particle modified to incorporate a Hyaluronic Acid moiety, targeting increased CD44 expression in endometrial cancer cells.
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Published on 2020-07-01